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Имеет длительный период полувыведения — 60–75 часов. Легко проходит через гистогематические барьеры, хорошо проникает в синовиальную жидкость. Количество проникающего через кожу теноксикама пропорционально площади, на которую он наносится, а также зависит от суммарной дозы препарата и степени гидратации кожи.